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PLGA Microspheres Containing Hydrophobically Modified Magnesium Hydroxide Particles for Acid NeutralizationMediated Anti-Inflammation

Kim JK, Go EJ, Ko KW, Oh HJ, Han J, Han DK, Park W

BACKGROUND: Poly(lactic-co-glycolic acid) (PLGA) microspheres have been actively used in various pharmaceutical formulations because they can sustain active pharmaceutical ingredient release and are easy to administer into the body using...
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Comparative Analysis of MSC-Derived Exosomes Depending on Cell Culture Media for Regenerative Bioactivity

Kim JY, Rhim WK, Seo HJ, Lee JY, Park CG, Han DK

BACKGROUND: In order to produce and isolate the exosome derived from the cell of interests, a serum free environment (starvation) has been essential for excluding the unknown effect from serum-derived...
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Analyses of Risk Factors of Age-related Macular Degeneration Using Routine Health Check-up Data

Han DK, Kim HK

Purpose: To investigate risk factors of age-related macular degeneration (AMD) with routine health check-up data. Methods: Among 9,019 patients older than 40 years who underwent a routine health checkup at a...
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Attenuation of Tumor Necrosis Factor-α Induced Inflammation by Umbilical Cord-Mesenchymal Stem Cell Derived Exosome-Mimetic Nanovesicles in Endothelial Cells

Ko KW, Yoo YI, Kim JY, Choi B, Park SB, Park W, Rhim WK, Han DK

Background: Inflammation induces dysfunction of endothelial cells via inflammatory cell adhesion, and this phenomenon and reactive oxygen species accumulation are pivotal triggers for atherosclerosis-related vascular disease. Although exosomes are excellent...
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New York City Vascular Surgeons during the COVID-19 Pandemic

Han DK

The coronavirus disease 2019 (COVID-19) pandemic has forever changed the lives of many across the world. Like many others, New Yorkers witnessed their hospital systems become overwhelmed with a massive...
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Two Cases of Uveo-meningeal Syndrome

Han DK, Kyung SE

PURPOSE: We report two cases of uveo-meningeal syndrome involving the retina, uvea, and optic disc in both eyes after viral meningitis. CASE SUMMARY: A 16-year-old female was referred to our department...
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In Vivo Safety and Regeneration of Long-Term Transported Amniotic Fluid Stem Cells for Renal Regeneration

Yu NH, Chun SY, Ha YS, Kim HT, Lih E, Kim DH, Kim J, Chung JW, Song PH, Yoo ES, Chung SK, Han DK, Kim BS, Kwon TG

BACKGROUND: Despite major progress in stem cell therapy, our knowledge of the characteristics and tissue regeneration potency of long-term transported cells is insufficient. In a previous in vitro study, we...
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A Novel Dorsal Slit Approached Non-Ischemic Partial Nephrectomy Method for a Renal Tissue Regeneration in a Mouse Model

Chun SY, Kim DH, Kim JS, Kim HT, Yoo ES, Chung JW, Ha YS, Song PH, Joung YK, Han DK, Chung SK, Kim BS, Kwon TG

BACKGROUND: Kidney ischemia-reperfusion (IR) via laparotomy is a conventional method for kidney surgery in a mouse model. However, IR, an invasive procedure, can cause serious acute and chronic complications through...
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In Vivo Validation Model of a Novel Anti-Inflammatory Scaffold in Interleukin-10 Knockout Mouse

Kim JY, Chun SY, Lee SH, Lih E, Kim J, Kim DH, Ha YS, Chung JW, Lee JN, Kim BS, Kim HT, Yoo ES, Han DK, Kwon TG, Jang BI

BACKGROUND: We fabricated anti-inflammatory scaffold using Mg(OH)2-incorporated polylactic acid-polyglycolic acid copolymer (MH-PLGA). To demonstrate the anti-inflammatory effects of the MH-PLGA scaffold, an animal model should be sensitive to inflammatory responses....
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Dose-Decreasing Effect of the First Reversed Laser Beam Collimator for C-Arm Type Angiographic Equipment

Heo YC, Cho JH, Han DK

This is a study on the dose-decreasing effect of the first reversed laser beam collimator (RLBC) for C-arm type angiographic equipment. A laser beam was located at the center of...
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Effect of DA-9701 on the Normal Motility and Clonidine-induced Hypomotility of the Gastric Antrum in Rats

Kang JW, Han DK, Kim ON, Lee KJ

  • KMID: 2203584
  • J Neurogastroenterol Motil.
  • 2016 Apr;22(2):304-309.
  • doi: 10.5056/jnm15131
BACKGROUND/AIMS: DA-9701 is a novel prokinetic agent. In the present study, we investigated the effect of DA-9701 on the motility of the gastric antrum in the normal and clonidine-induced hypomotility...
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Association of Cognitive Dysfunction with Thyroid Autoantibody

Han DK, Cheon JS, Choi YS, Kim HC, Oh BH

OBJECTIVES: The aims of this study were to know the frequency of cognitive dysfunction among patients with autoimmune thyroid disorders, and to reveal influencing factors on it, especially to clarify...
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Graves disease following rabbit antithymocyte globulin treatment of severe aplastic anemia in a Korean child

Choi IS, Kim HK, Han DK, Baek HJ, Jang HI, Kim CJ, Kook H

Antithymocyte globulin (ATG) is used as an immunosuppressive treatment (IST) to deplete clonal suppressor T cells in patients with severe aplastic anemia (SAA). The depletion of suppressor T cells by...
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Alveolar rhabdomyosarcoma with massive disseminated intravascular coagulopathy treated with systemic chemotherapy

Yoon BG, Baek HJ, Oh BS, Han DK, Choi YD, Kook H

It is uncommon for pediatric patients with rhabdomyosarcoma to present with clinical and/or laboratory features of disseminated intravascular coagulation (DIC). We report a case of metastatic alveolar rhabdomyosarcoma with severe...
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Thyroid autoimmunity in children and adolescents with newly diagnosed type 1 diabetes mellitus

Jung ES, Han DK, Yang EM, Kim MS, Lee DY, Kim CJ

PURPOSE: This study aim to investigate the occurrence of autoimmune thyroid disease in children and adolescents at onset of type 1 diabetes mellitus (T1DM) and to assess whether the presence...
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Long-term follow-up of Fanconi anemia: clinical manifestation and treatment outcome

Yoon BG, Kim HN, Han UJ, Jang HI, Han DK, Baek HJ, Hwang TJ, Kook H

PURPOSE: The aim of this study was to characterize Korean patients with Fanconi anemia (FA), which is a rare but very challenging genetic disease. METHODS: The medical records of 12 FA...
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Hereditary hemolytic anemia in Korea from 2007 to 2011: A study by the Korean Hereditary Hemolytic Anemia Working Party of the Korean Society of Hematology

Park ES, Jung HL, Kim HJ, Park SS, Bae SH, Shin HY, Song SH, Koh KN, Lyu CJ, Lim YT, Han DK, Hah JO

BACKGROUND: The number of patients diagnosed with hereditary hemolytic anemia (HHA) has increased since the advent of novel diagnostic techniques that accurately identify this disorder. Here, we report data from...
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Growing Teratoma Syndrome of the Pineal Gland Recognized Very Early during Chemotherapy in a Child with a Non-Germinomatous Germ-Cell Tumor

Zhang Z, Yoon BG, Baek HJ, Park SJ, Han DK, Park SM, Jung TY, Lee MC, Kook H

  • KMID: 2049298
  • Clin Pediatr Hematol Oncol.
  • 2013 Apr;20(1):75-78.
The growing teratoma syndrome (GTS) is defined as the development of mature low-grade elements in the absence of a recurrent non-germinomatous germ-cell tumor (NGGCT) after partial response to multimodal treatment....
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Multiple Ecthyma Gangrenosum in a Hemophagocytic Lymphohistiocytosis Patient

Park BM, Yun SJ, Han DK, Kook H, Lee JB, Lee SC, Won YH, Kim SJ

  • KMID: 2247248
  • Korean J Dermatol.
  • 2013 Mar;51(3):223-224.
No abstract available.
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Implication of Early Lymphocyte Recovery after Allogeneic Hematopoietic Stem Cell Transplantation in Children with Leukemia

Han DK, Baek HJ, Kim SY, Hwang TJ, Kook H

PURPOSE: The repopulating lymphocytes after allogeneic hematopoietic stem cell transplantation have an important role not only on the prevention of serious infections in the early transplantation period, but also on...
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