J Clin Neurol.  2009 Sep;5(3):151-152. 10.3988/jcn.2009.5.3.151.

Anti-Ri-Antibody-Associated Paraneoplastic Syndrome in a Man with Breast Cancer Showing a Reversible Pontine Lesion on MRI

• Kim H
• Lim Y
• Kim KK

• KMID: 2045423
• DOI: http://doi.org/10.3988/jcn.2009.5.3.151

Abstract

BACKGROUND
Paraneoplastic neurological disorders associated with anti-Ri-antibodies, which are typically present with opsoclonus-myoclonus-ataxia. Most cases with anti-Ri-antibodyassociated paraneoplastic syndrome due to breast cancer occur in women - its occurrence in men is extremely rare. CASE REPORT: We present herein the case of a male patient with breast cancer who had atypical anti-Ri-antibody-associated paraneoplastic syndrome presenting as complete horizontal ophthalmoplegia, left trigeminal sensory symptoms, and truncal ataxia. Following the diagnosis of paraneoplastic syndrome, chemotherapy and immunomodulating treatment including intravenous immunoglobulin and oral prednisolone were administered. Although the patient was negative for serum anti-Ri-antibodies 14 weeks later, his symptoms persisted. CONCLUSIONS: To our knowledge, this is the first case report of ophthalmoplegia without opsoclonus-myoclonus in a male anti-Ri-antibody-positive patient with breast cancer.

Keyword

breast cancer; anti-Ri-antibody; paraneoplastic syndrome

MeSH Terms

Ataxia
Breast
Breast Neoplasms
Female
Humans
Immunoglobulins
Male
Multiple Endocrine Neoplasia Type 1
Nervous System Diseases
Ophthalmoplegia
Paraneoplastic Syndromes
Prednisolone
Immunoglobulins
Prednisolone