J Korean Ophthalmol Soc.  1986 Dec;27(6):1073-1076.

Effeet of Timolol on Aqueous Humor Protein Concentration

• Ahn CS

Abstract

The Beta-adrenergic blocker(timolol maleate) decreases intraocular pressure by reducing the production of aqueous humor. Twenty patients scheduled to undergo cataract extraction were induced in study. After timolol maleate administration, we found the increase in the total protein concentration. By double-masked controlled study, 0.5% timolol maleate solution and normal saline were applied topically, and aqueous humor was aspirated during surgery. Total protein concentrations were determined by HPGFC. The total protein concentration as well as the concentration of high, medium and low molecular weight protein were elevated in the timololadministrated group. The relation of the levels of the three different molecular weight classes did not differ significantly between the timolol maleate group and the normal group.

MeSH Terms

Aqueous Humor*
Cataract Extraction
Humans
Intraocular Pressure
Molecular Weight
Timolol*
Timolol