Evaluation of the Tosoh HLC-723 G8 HbA1c Autoanalyzer

Kwon, Aerin; Park, Ji Young; Kim, Jae Seok

Abstract

BACKGROUND
We evaluated overall performance and analysis time of newly developed HLC-723 G8 (Tosoh corp., Tokyo, Japan) HbA1c autoanalyzerwhich utilizes cation-exchange HPLC method.
METHODS
Linearity, precision, correlation with Variant II Turbo (Bio-Rad Laboratories, Hercules, CA, USA), analysis time, labile HbA1c (L-A1c) separation ability and stability of refrigerated sample at 4degrees C were evaluated.
RESULTS
HLC-723 G8 showed good linearity between HbA1c 4.9-12.0% range (R2=0.9995). Within-run and total imprecision (CVs) were less than 1.0%. Correlation with Variant II Turbo and L-A1c separation ability were excellent. Analysis time per sample took 1.0 min. Stability of refrigerated sample at 4degrees C for at least 21 days was good.
CONCLUSIONS
HLC-723 G8 showed good analytical performance and its rapid analysis time enables us to support outpatient diagnosis of diabetic patients efficiently.