J Korean Soc Vasc Surg.
2000 Apr;16(1):18-24.
Morphological Changes of the Endothelial Cell under the Influence of the Hemodynamic Stresses
- Affiliations
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- 1Department of Mechanical Engineering, SoongSil University, College of Engineering, Korea. suhsangho@sfel.ssu.ac.kr
- 2Department of Mechanical Engineering and Design, Hankuk Aviation University, Korea.
- 3Institiute of Advanced Machinery and Design, Seoul National University, Korea.
- 4Division of Vascular Surgery, Samsung Medical Center, College of Medicine, Sungkyunkwan University, Korea.
Abstract
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PURPOSE: The objective of this study is to investigate the effects of hemodynamics on morphological changes of human endothelial cells.
METHODS
The changes under the laminar flow condition are investigated by the in-vitro experiment and computer simulation. Micrographs of the endothelial cells in the laminar flow chamber are taken as a function of the exposed time. Idealized geometric shapes of the cells whose shapes are changing with the exposed time due to the flow stresses are portrayed by the computer simulation. Drag force on the cell due to the pressure and shear stress is calculated for two constraining conditions, that is, the cell changes its shape keeping its initial volume or initial surface area.
RESULTS
AND CONCLUSION: The drag force of the cell which keeps constant volume is smaller than that of the cell which keeps constant surface area.
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