J Korean Soc Radiol.  2010 May;62(5):421-425. 10.3348/jksr.2010.62.5.421.

Myeloid Sarcoma Presenting as Multiple Lymphadenopathy: A Case Report

• Hong SH
• Suh SI
• Seol HY
• Cho JG
• Shin BK

• KMID: 2002948
• DOI: http://doi.org/10.3348/jksr.2010.62.5.421

Abstract

Myeloid sarcoma manifesting as multiple lymphadenopathy is quite rare. We present here a case of myeloid sarcoma that first presented with palpable bilateral neck masses. A 53-year-old woman complained about repetitive swelling in the right infraauricular and submental areas for 3 years. The results of computed tomography showed multiple lymphadenopathy in both areas of the neck as well as other parts of the body. So, the presumptive diagnosis was lymphoma, but the result of the excisional biopsy of the neck mass confirmed it to be a myeloid sarcoma.

MeSH Terms

Biopsy
Female
Humans
Lymphatic Diseases
Lymphoma
Middle Aged
Neck
Sarcoma, Myeloid
Tomography, X-Ray Computed

Figure

• 

  Fig. 1 A 53-year-old woman with bilateral palpable cervical masses. A, B. The contrast-enhanced CT scan shows bilateral lymphadenopathy at the level of the mandible (A) and thyroid gland (B). The largest one in the left supraclavicular fossa (B, arrow) is a lobular shaped, homogeneously enhanced, isodense mass that has the same enhancement as the adjacent skeletal muscle. C-F. The contrast-enhanced CT scan also shows multiple well-demarcated homogeneously enhancing enlarged lymph nodes in the both axillae, the mediastinum and the retroperitoneum (arrows).

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  Fig. 2 Microscopic findings of the cervical lymph node. The normal architecture of the excised node was completely effaced (A. H & E, ×12.5) with infiltration of blastic cells (B. H & E, ×400). On immunohistochemistry, these cells were diffusely reactive for CD34 (C. CD34, ×400) and also for MPO in a characteristic granular pattern (D. MPO, ×400).

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