Korean J Urol.  2007 Mar;48(3):356-358. 10.4111/kju.2007.48.3.356.

Primary Bladder Signet Ring Cell Carcinoma Extended to Prostate

• Woo JH
• Park HJ
• Kim EK
• Kang JY
• Jeong JY
• Yoo TK

• KMID: 1997138
• DOI: http://doi.org/10.4111/kju.2007.48.3.356

Abstract

A primary signet ring cell carcinoma (PSRCC) of the urinary bladder is a rare variant of a mucin-producing adenocarcinoma. The prognosis of a PSRCC is poor, as silent progression in a linitis platica fashion leads to delayed diagnosis. Herein, the case of a PSRCC of the bladder, which extended to the prostate, which was treated with a cystoprostatectomy, is reported.

Keyword

Carcinoma, signet ring cell; Bladder

MeSH Terms

Adenocarcinoma
Carcinoma, Signet Ring Cell*
Delayed Diagnosis
Prognosis
Prostate*
Urinary Bladder*

Figure

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  Fig. 1 (A) Prostatic urethral mass on cystoscopy. (B) Normal prostatic glands are seen on the left side, with dense tumor cells seen on the right side (H&E, ×100).

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  Fig. 2 Post-transurethral resection (TUR) pelvic computer tomography showing multiple bladder wall thickening (A) and a filling defect of the left bladder base (B).

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  Fig. 3 (A) Microscopic findings of a signet ring cell carcinoma. A histological examination revealed a predominance of cancer cells forming abundant mucin. Periodic acid-Schiff stain was positive (×400). (B) Prostate-specific antigen (PSA) stain showing no staining of the cancer cell (×100).

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