Korean J Obstet Gynecol.  2012 Apr;55(4):265-268. 10.5468/KJOG.2012.55.4.265.

A case of spindle cell carcinoma of the uterine cervix

Affiliations
  • 1Department of Obstetrics and Gynecology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea. drsook@schmc.ac.kr
  • 2Department of Pathology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea.

Abstract

Spindle cell carcinoma is a rare variant of squamous cell carcinoma characterized histologically by a biphasic pattern with both squamous and spindle cell component. There is controversy in the histogenesis, biologic behavior, optimal treatment and prognostic factor for tumor. Treatment must be similar for squamous cell carcinoma. With a review of literature, we report a case of a 52-year-old female with spindle cell carcinoma in the uterine cervix, which has been managed by total hysterectomy.

Keyword

Spindle cell carcinoma; Uterine cervix; Hysterectomy

MeSH Terms

Carcinoma, Squamous Cell
Cellular Structures
Cervix Uteri
Female
Humans
Hysterectomy
Middle Aged

Figure

  • Fig. 1 Punch biopsy reveals carcinoma composed of spindle cells (H&E, ×200).

  • Fig. 2 (A) Cone biopsy of the cervix shows squamous cell carcinoma, focal fascicles of proliferating spindle cell, which considerable mitotic activity, and focal moderate degree of nuclear atypia (H&E, ×400). (B) Immunohistochemical finding shows positive reaction for smooth muscle actin (smooth muscle antigen, ×400).


Reference

1. Kim BS, Park JH, Park YK, Kim KS. A case of spindle cell carcinoma accompanied by inverted papilloma. Korean J Otolaryngol-Head Neck Surg. 2003. 46:520–523.
2. Ferlito A. Histological classification of larynx and hypopharynx cancers and their clinical implications. Pathologic aspects of 2052 malignant neoplasms diagnosed at the ORL Department of Padua University from 1966 to 1976. Acta Otolaryngol Suppl. 1976. 342:1–88.
3. Randall G, Alonso WA, Ogura JH. Spindle cell carcinoma (pseudosarcoma) of the larynx. Arch Otolaryngol. 1975. 101:63–66.
4. Olsen KD, Lewis JE, Suman VJ. Spindle cell carcinoma of the larynx and hypopharynx. Otolaryngol Head Neck Surg. 1997. 116:47–52.
5. Recher G. Spindle cell squamous carcinoma of the larynx. Clinico-pathological study of seven cases. J Laryngol Otol. 1985. 99:871–879.
6. Ballo MT, Garden AS, El-Naggar AK, Gillenwater AM, Morrison WH, Goepfert H, et al. Radiation therapy for early stage (T1-T2) sarcomatoid carcinoma of true vocal cords: outcomes and patterns of failure. Laryngoscope. 1998. 108:760–763.
7. Kim HY, Kim HJ, Choi G, Choi JO. A case of sarcomatoid carcinoma of nasal cavity. Korean J Otolaryngol-Head Neck Surg. 1996. 39:1705–1709.
8. Lane N. Pseudosarcoma (polypoid sarcoma-like masses) associated with squamous-cell carcinoma of the mouth, fauces, and larynx; report of ten cases. Cancer. 1957. 10:19–41.
9. Minami SB, Shinden S, Yamashita T. Spindle cell carcinoma of the palatine tonsil: report of a diagnostic pitfall and literature review. Am J Otolaryngol. 2008. 29:123–125.
10. Thompson LD, Wieneke JA, Miettinen M, Heffner DK. Spindle cell (sarcomatoid) carcinomas of the larynx: a clinicopathologic study of 187 cases. Am J Surg Pathol. 2002. 26:153–170.
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