Korean J Obstet Gynecol.  2012 Jul;55(7):507-512. 10.5468/KJOG.2012.55.7.507.

A Case of Recurrent Ovarian Granulosa Cell Tumor Associated with Sarcomatoid Change

• Lee JO
• Lee JJ
• Lee DH
• Kim MJ
• Lee DJ

• KMID: 1992561
• DOI: http://doi.org/10.5468/KJOG.2012.55.7.507

Abstract

Granulosa cell tumors of the ovary are malignancies that originate from the sex-cord stromal cells of the ovary and represent 2% to 5% of all ovarian cancers. Slow growth with a tendency for late recurrence characterizes a natural history of this tumor. So this tumor needs a prolonged follow-up. As a result of recent literature in Korea, the findings are 3 cases of juvenile granulosa cell tumor and 1 case of adult granulosa cell tumor. Previous case of adult granulosa cell tumor was presented recurrence with hepatic metastasis after 9 months of first diagnosis and operation. We describe here a 52-year-old women with recurrent granulosa cell tumor after total abdominal hysterectomy with right salpingo-oophorectomy and left ovarian wedge resection because of right ovarian granulosa cell tumor 12 years ago. Our case presented late recurrence character of granulosa cell tumor. We report 1 case of recurrent adult type granulosa cell tumor associated sarcomatoid change with a brief review of literatures.

Keyword

Granulosa cell tumor; Recurrent; Sarcomatoid change

MeSH Terms

Adult
Female
Follow-Up Studies
Granulosa Cell Tumor
Granulosa Cells
Humans
Hysterectomy
Korea
Middle Aged
Natural History
Neoplasm Metastasis
Ovarian Neoplasms
Ovary
Recurrence
Stromal Cells

Figure

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  Fig. 1 Pelvic computed tomography shows about 20 cm sized huge, lobulated, well-marginated cystic and solid mixed density mass lesion is seen in the pelvic cavity. (A) Non-enhance phase. (B) Delayed phase.

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  Fig. 2 The sectioned surface of the tumor is solid, yellow to tan with focal cystic areas. Focal necrosis is also noted.

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  Fig. 3 (A) Left ovary has normal appearance (H&E, ×10). (B) The tumor shows highly cellular diffuse growth pattern (H&E, ×100).

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  Fig. 4 Mitotic figures are readily identified. The cells have occasional nuclear grooves (H&E, ×200).

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  Fig. 5 Immunostains for alpha-inhibin and CD99 shows a diffuse, intensely positive reaction (Immunohistochemistry, ×200).

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