J Korean Assoc Oral Maxillofac Surg.  2000 Apr;26(2):186-190.

THE CHANGES OF IMMUNOGLOBULIN ISOTYPES IN WHOLE SALIVA IN INFECTED PATIENTS OF ORAL AND MAXILLOFACIAL REGION

• Byun JH
• Chung IK

Abstract

PURPOSE
The purpose of this study is to observe the salivary immunoglobulin level in whole saliva of infected patients and also to investigate the changes of immunoglobulin level according to its management.
MATERIALS AND METHODS
Thirty infected patients who have been admitted to the dept. of oral and maxillofacial surgery of Pusan National University Hospital have been selected as subjects and we analysed the changes of immunoglobulin level of 1.5~3.0ml of unstimulated whole saliva collected throughout four times; the day before treatment, the first day after treatment, the third day after treatment and the day before discharge. We also compared them with immunoglobulins in whole saliva that was collected from 4 normal persons as control group. In radial immunodiffusion technique with BACKMAN(Array 360 system, McLean, USA), level of immunoglobulins was analyzed.
RESULTS
The isotypes of Ig that have been found in saliva of normal persons were IgG, IgA, IgM and IgE and their mean level was 8.23, 36.41, 4.38, and 2.38 respectively. In the infected patients before the treatment, the level of IgG, IgA was remarkably higher than that of normal persons, however we could not find the difference on the level of IgM, IgE. As the infection was healing, the level of IgG, IgA was decresing significantly.

Keyword

Infection; Saliva; Immunoglobulin

MeSH Terms

Busan
Humans
Immunodiffusion
Immunoglobulin A
Immunoglobulin E
Immunoglobulin G
Immunoglobulin Isotypes*
Immunoglobulin M
Immunoglobulins*
Saliva*
Surgery, Oral
Immunoglobulin A
Immunoglobulin E
Immunoglobulin G
Immunoglobulin Isotypes
Immunoglobulin M
Immunoglobulins