J Korean Assoc Oral Maxillofac Surg.  2000 Apr;26(2):179-185.

Development of moldable bone regenerating therapeutics using partially purified porcine bone morphogenetic protein and bioresorbable polymer

• Lee JH
• Chung CP
• Lee SJ

Abstract

The purpose of this study was to develop an osteogenic, biodegradable material using polymer and BMP. It was designed to have structural function and be moldable, for the reconstruction of load bearing areas and deformities of various configurations. Bone apatite was added to Poly(L-lactide)(PLLA) and made porous for osteoconductability and ease of BMP loading. The materials, with or without BMP purified from porcine bone matrix, were evaluated in cranial bone defect models in rats for biocompatibility and bone regeneration capability. The following results were obtained: The PLLA-BMP material with BMP added to the polymer showed 30% healing of cranial bone defects in rats during the 2 weeks to 3 months period of observation. The moldable PLLA agent without BMP also showed 25% bone healing capacity. Although new bone formation was incomplete in the critical size defect of rat cranium, it can be concluded that the unique moldability of those agents makes them useful for the reconstruction of various bone defects and maxillofacial deformities.

Keyword

Bioresorbable polymer; BMP; Bone regenerating therapeutics

MeSH Terms

Animals
Bone Matrix
Bone Morphogenetic Proteins*
Bone Regeneration
Congenital Abnormalities
Osteogenesis
Polymers*
Rats
Skull
Weight-Bearing
Bone Morphogenetic Proteins
Polymers