J Korean Neurosurg Soc.  1991 Nov;20(10-11):900-904.

The Experimental Study for the Reaction of the Hemostatic Agents to the Surrounding Brain Tissue

• Chang HS
• Kim KT
• Song SH
• Kim SH
• Kim Y

Abstract

In a series of 20 young rats, three cortical lesions were made in each hemisphere. Two of these lesions were filled with avitene and gelfoam, while the third was left empty as a control. The animals were killed successively on weeks 1, 2, 4 and 8 after the operation. The results were as follows : 1) Although there was no difference in the type of tissue reactions, avitene was more rapid and profound than gelfoam in the process and degree of inflammatory reaction at the same periods. 2) Avitene biodegradaded more rapidly than gelfoam. 3) The extent of fibrosis and adhesion to the surrounding brain tissues were not grossly different between these two agents but more profound histopathologically in avitene at the same periods. With these results, we could conclude that the avitene was superior to the gelfoam as the hemostatic agent in neurosurgical area.

MeSH Terms

Animals
Brain*
Collagen
Fibrosis
Gelatin Sponge, Absorbable
Rats
Collagen