J Korean Ophthalmol Soc.  1995 Aug;36(8):1363-1369.

Histopathological Findings of Schnyder's Crystalline Corneal Dystrophy

• Kim JH
• Myong YW

Abstract

Schnyder's crystalline corneal dystrophy is a hereditary disease of unknown etiology, and characterized by bilateral subepithelial corneal opacification with crystalline or diffuse deposits of cholesterol or other lipid. It is rare and has never been reported in Korea. The authors experienced a case of Schnyder's crystallin corneal dystrophy examined in a 36-year-old man who had bilateral corneal crystalline deposits since 15 years old and significant reduction in vision for two years. Light microscopic examination of patient's keratoplasty specimen showed lipid deposits in the superficial stroma, and electron microscopy disclosed multiple lipid vacuoles in basal epithelium, Bowman slayer, superficial stroma and keratocytes. In this report, we describe the histopathological findings of Schnyder's crystalline corneal dystrophy.

Keyword

Corneal opacity; Lipid deposits; Schnyder's crystalline dystrophy

MeSH Terms

Adolescent
Adult
Cholesterol
Corneal Opacity
Corneal Transplantation
Crystallins*
Epithelium
Genetic Diseases, Inborn
Humans
Korea
Microscopy, Electron
Vacuoles
Cholesterol
Crystallins