J Korean Ophthalmol Soc.
1992 Jun;33(6):622-626.
The Changes of the Visual Evoked Potential for Aconitine Induced Visual Pathway Demyelination in Rabbit Model
- Affiliations
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- 1Department of Ophthalmology, School of Medicine Kyungpook National University, Taegu, Korea.
Abstract
- Aconitine, a principal constituent of aconite, may cause myelopathy on the visual pathway, spinal cord and peripheral nerve of the rabbits. A single dose of aconitine (O.6mg/kg), was administered intraperitoneally in order to analyze electrophysiological change of the eye in a rabbit model. The changes of the VEP after an aconitine injection consisted of delay in the onset and peak latency, and a reduction in the amplitude of the contralateral a cortical response. The amplitude of YEP was reduced prominently for several days after the aconitine injection and thereafter recovered quickly. However, the onset and peak latency were significantly delayed until 8 weeks after the aconitine injection. The analysis of YEP afttords us an excellent opportunity to access the precise structural correlates of the functional changes associated with demyelination within the central nervous system in rabbits.
