J Korean Surg Soc.  1998 May;54(5):738-742.

Coagulation Factor Abnormality of Deep Vein Thrombosis in Korea

• Kim DI
• Huh S
• Chang HS
• Lee TS
• Chang JB
• Joh JH
• Kim YI
• Lee BB

Abstract

A deep vein thrombosis(DVT) is responsible for a number of significant medical problems including pulmonary embolisms. The factors that cause DVT have been studied by many investigators. The cases of 31 DVT patients, 19 males and 12 females, who were treated from January 1994 through January 1996, were reviewed. The mean age was 47.3 15.9 years. Four cases(12.9%) affected the right leg, 25 cases(80.6%) on the left leg, and 2 cases(6.5%) the portal vein and the mesenteric vein. Among the 29 lower extremity DVT cases, 16 cases(51.6%) showed ipsilateral iliac vein thromboses and 1 case(3.2%) showed an inferior vena cava thrombosis. Five cases(16.1%) had a history of an explo-laparotomy, 2 cases(6.5%) had a history of immobilization, 1 case(3.2%) had a history of trauma to the involved leg, and 2 cases(6.5%) had a history of collagen disease. However, 21 cases(67.7%) had no history of any predisposing factors. Five cases(16.1%) were confirmed as protein C deficiency, 3 cases(9.7%) as protein S deficiency, 4 cases(12.9%) as antithrombin III deficiency, 3 cases(9.7%) as plasminogen deficiency, and 6 cases(19.4%) as -2 antiplasmin deficiency. Ten(32.3%) of the 31 cases had multiple coagulation factor deficiency. Three patients(9.7%) had been inserted with Greenfield filter into the inferior vena cava. Initially, unfractionated heparin was injected intravenously under the control of the activated partial thromboplastin time(aPTT) until the warfarin effect reached INR 1.75~2.0. Only 5 of the 31 cases agreed to a family to study to detect any possible coagulation factor abnormality. Three of these 5 families showed coagulation factor abnormality. Our results show that more extensive study on DVT is needed in the Korean population.

Keyword

Thrombosis; Venous; Coagulation; Protein C; Protein S; Antithrombin III

MeSH Terms

Antithrombin III
Antithrombin III Deficiency
Blood Coagulation Factors*
Causality
Collagen Diseases
Female
Heparin
Humans
Iliac Vein
Immobilization
International Normalized Ratio
Korea*
Leg
Lower Extremity
Male
Mesenteric Veins
Plasminogen
Portal Vein
Protein C
Protein C Deficiency
Protein S
Protein S Deficiency
Pulmonary Embolism
Research Personnel
Thromboplastin
Thrombosis
Veins
Vena Cava, Inferior
Venous Thrombosis*
Warfarin
Antithrombin III
Blood Coagulation Factors
Heparin
Plasminogen
Protein C
Protein S
Thromboplastin
Warfarin