Korean J Gastrointest Endosc.  2011 Feb;42(2):74-82.

Regression of Hyperplastic Gastric Polyp after Helicobacter pylori Eradication

  • 1Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. gi7pjj@yahoo.co.kr
  • 2Department of Occupational & Environmental Medicine, Korea University College of Medicine, Ansan, Korea.


Recent studies have suggested that the eradication of Helicobacter pylori (Hp) may lead to the regression of hyperplastic polyps (HPPs) in the stomach. We evaluated the sizes of HPPs after Hp eradication and we also compared the clinical parameters between the regression and non-regression groups.
We enrolled 187 patients who had HPPs in the stomach. The polyps were measured by using biopsy forceps, and the endoscopically observed changes of the polyps were assessed by two endoscopists.
Total regression was observed in 68 patients of the eradicated group and in 6 patients in the non-eradicated group (42.5% vs. 22.2%, respectively, p<0.05). The non regression rate was significantly higher for the non-eradicated group than that for the eradicated group (33% vs. 10%, respectively, p<0.05). Comparing between the regression and non-regression groups, the incidence of polyps that were smaller than 10 mm in size and sessile was significantly higher in the regression group. Hp eradication was the only significant predictor of regression.
Hp eradication could be a therapeutic option for Hp positive-hyperplastic gastric polyps, and especially for those that are less than 10 mm in size and sessile.


Hyperplastic gastric polyp; Helicobacter pylori; Eradication; Regression; Predictive factor
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