Korean J Anesthesiol.  1996 Jun;30(6):750-754. 10.4097/kjae.1996.30.6.750.

Survival from Malignant Hyperthemia During General Anesthesia

• Lee KS
• Song YK
• Lee CS
• Kim TY

• KMID: 1934809
• DOI: http://doi.org/10.4097/kjae.1996.30.6.750

Abstract

We had a 52-year-old male presented for a surgery for old fracture of the 7th cervical vertebra. Generalized muscle rigidity and high fever with tachycardia was revealed 25 minutes after succinylcholine and enflurane administration. Then the body temperature was risen from 37.8 degrees C to 40.5 degrees C within 20 minutes and the arterial blood gas analysis showed a severe respiratory and metabolic acidosis. Under the suspicion of malignant hyperthermia, all anesthetics were discontinued, refrigerated intravenous solutions were started, and gastric lavage with cold saline was initiated together with packing the body with ice. Oral dantrolene 125mg, the only drug we could obtain, was administered through Levins tube after lavage. Serial serum CPK level were 4414 IU/L on third day and 74 IU/L on seventh day postoperatively. The postoperative course was uneventful and the patient could be walked after fifth day postoperatively and discharged without any sequelae.

Keyword

Anesthesia; general; Hyperthermia; malignant; Pharmacology; dantrolene

MeSH Terms

Acidosis
Anesthesia
Anesthesia, General*
Anesthetics
Blood Gas Analysis
Body Temperature
Dantrolene
Enflurane
Fever
Gastric Lavage
Humans
Ice
Male
Malignant Hyperthermia
Middle Aged
Muscle Rigidity
Pharmacology
Spine
Succinylcholine
Tachycardia
Therapeutic Irrigation
Anesthetics
Dantrolene
Enflurane
Ice
Succinylcholine