Korean J Leg Med.  2014 Nov;38(4):175-179. 10.7580/kjlm.2014.38.4.175.

Limitation of Regular Autosomal STR Testing for Paternity within an Isolated Population

• Cho S
• Yu HJ
• Han J
• Kim Y
• Seo HJ
• Lee SD

• KMID: 1928012
• DOI: http://doi.org/10.7580/kjlm.2014.38.4.175

Abstract

In order to determine paternity by genetic testing, the Paternity Index (PI) and probability of paternity are calculated using likelihood ratio method. However, when it is necessary, additional testing can be performed to validate the genetic relationship. This research demonstrates autosomal short tandem repeat (STR) results of Jeju Island population in order to determine genetic relationship. Two notable cases showed that despite the acceptable PI value obtained from STR testing, average of 12 mismatches were found in total of 169 autosomal single nucleotide polymorphism typing. Such cases imply that cautious statistical approach is necessary when determining genetic relationship, especially within an isolated population group. Moreover, this would suggest that a further research and investigation are needed in order to understand the population structure of Korea.

Keyword

Single nucleotide polymorphism; Paternity test; Oligonucleotide array sequence analysis

MeSH Terms

Genetic Testing
Humans
Korea
Microsatellite Repeats
Oligonucleotide Array Sequence Analysis
Paternity*
Polymorphism, Single Nucleotide
Population Groups

Reference

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