Korean J Nucl Med.  1999 Apr;33(2):222-227.

Dosimetry and MIRD for Re-188 Liquid Balloons

• Lee DS
• Lee J

Abstract

Re-188 is suitable for endovascular liquid-balloon brachytherapy for the prevention of restenosis after angioplasty. Re-188 was concentrated to 3700 MBq/ml and labeled with DTPA. According to dosimetric calculation, it took 420 seconds using Re-188 solution with concentration of 3700 MBq/ml to irradiate 17.6 Gy to the target at 1 mm from the balloon surface. Software was made to estimate the irradiation time. MIRD calculation with dynamic bladder model yielded the whole body dose of Re-188-DTPA as 0.005mGy/MBq in case of balloon rupture and release of the whole amount into the blood.

Keyword

Re-188 DTPA; Dosimetry; MIRD; Restenosis

MeSH Terms

Angioplasty
Brachytherapy
Pentetic Acid
Rupture
Urinary Bladder
Pentetic Acid