Current Chemotherapy of Wilms Tumor

Lee, Sang Gil; Han, Keun Ho

Abstract

A clinical observation was made of 14 cases of Wilms' tumor admitted to the Department of Urology, Keimyung University Medical College and Hospital during the period from January 1973 through May 1981. Clinical findings and therapeutic modalities with prognosis are summarized below: 1. The range in age is from 2 months to 11 years, average 3.9 years. 2. Common symptoms are painless palpable abdominal mass, abdominal pain and hematuria. 3. The characteristic urographic findings are as follows: Calyceal distortions in 7 cases, non-visualizing kidney in 3 cases and hydronephrosis in 2 cases. Lung metastases were noted in 5 cases on chest X-ray. 4. Clinical stages according to the National Wilms` Tumor Study criteria are as follows : Stage I in 6 cases. II in 1 case, III in 2 cases and IV in 5 cases. 5. Modalities of treatment are chiefly as follows: Nephrectomy only in 2 cases, Nephrectomy+radiation therapy in 2 cases, Nephrectomy+radiation therapy+single AMD course in 2 cages and Nephrectomy+multiple AMD & VCR course in 6 patients. 6. 2 and 1/2 year survival rates according to the clinical stages are as follows: Stage I 4/4 II 1/1 III 1/2 and IV 1/2. 7. 2 and 1/2 year survival rates according to the age groups are as follows : -2 years 4/4, 2 years - 5 years 0/2, and 5 years -2/3. 8. Side effects of multiple AMD & VCR courses are as follows: Vomiting 4, alopecia 4, leukopenia 2, anemia 1, abdominal pain 1, fever 1, Those were corrected with conservative treatment.