Korean J Nephrol.  2010 May;29(3):371-375.

Spontaneous Remission of Nephrotic Syndrome in IgA Nephropathy

• Kim JH
• Kim H
• Hong SM
• Kie JH
• Kang EW
• Shin SK
• Han SH

Abstract

Although a moderate degree of proteinuria is common in patients with IgA nephropathy (IgAN), nephrotic syndrome combined with IgAN is rare. It has been reported that approximately 5% of all patients with IgAN are complicated by minimal change disease and these patients respond well to corticosteroid therapy. However, spontaneous remission is uncommon in heavy proteinuric patients with IgAN. Recently, we experienced two cases of spontaneous remission of nephrotic syndrome combined with IgAN without use of corticosteroid. In these patients, heavy proteinuria disappeared in 1 month after the onset and no recurrence occurred during follow-up. With such limited number of cases, factors associated with spontaneous remission in these patients could not be explored. Further study with a larger number of patients is required and careful attention should be paid to these complicated cases.

Keyword

IgA nephropathy; Nephrotic syndrome; Spontaneous remission

MeSH Terms

Follow-Up Studies
Glomerulonephritis, IGA
Humans
Immunoglobulin A
Nephrosis, Lipoid
Nephrotic Syndrome
Proteinuria
Recurrence
Remission, Spontaneous
Immunoglobulin A