J Korean Soc Ther Radiol Oncol.  1998 Jun;16(2):115-123.

Chromosomal Aberration in Fractionated Radiotherapy

• Yun HG
• Ha SW

Abstract

PURPOSE: This study was tried to evaluate the effect of the partial body fractionated irradiation on the frequency of chromosomal aberration.
MATERIALS AND METHODS
In three patients with uterine cervix carcinoma, chromosomal aberrations were analyzed during fractionated external beam radiotherapy. Radiation field included whole pelvis and total dose was 5040 cGy in 28 fractions.
RESULTS
The values of the frequency of dicentrics and rings (Ydr) in pre- irradiated peripheral lymphocytes in three patients were 0.0060, 0.0000, and 0.0029, respectively. The frequency of dicentrics and rings, estimated during the course of radiotherapy, increased with radiation dose and best fitted to the linear equation, Ydr=7.31x10(-5) D(cGy)+1.45x10(-2). The frequency of dicentrics and rings among the cells with dicentric and/or ring (Qdr) also showed increasing tendency and best fitted to the linear equation, Qdr= 1.01x10(-4) D(cGy)+1.04.
CONCLUSION
Ydr increased linearly with radiation dose in the dose range of our study, and Qdr showed increasing tendency with dose.

Keyword

Biological dosimetry; Chromosomal aberration; Lymphocyte; Fractionated radiotherapy

MeSH Terms

Cervix Uteri
Chromosome Aberrations*
Female
Humans
Lymphocytes
Pelvis
Radiotherapy*