Korean J Clin Pathol.  1999 Dec;19(6):741-745.

Cytogenetic Analysis for Amenorrhea

Affiliations
  • 1Department of Clinical Pathology, Medical College of Kyung Hee University, Seoul, Korea

Abstract

BACKGROUND
Chromosomal aberration is one of the major causes of amenorrhea. So we studied the incidence and the clinical importance of chromosomal aberration in patients with amenorrhea.
METHODS
Cytogenetic investigations were carried out on 101 women with amenorrhea from Jan. 1990 to Dec. 1998. Peripheral blood lymphocytes were cultured for chromosomal studies by the standard method.
RESULTS
In primary amenorrhea, 27 cases (38.6%) showed aberrations of chromosome. 45,X and their mosaicism were 14 cases (20.0%), structural anomalies of the X chromosome were 6 cases (8.6%) and the presence of Y chromosome, 5 cases (7.1%). In secondary amenorrhea, one case (3.2%) showed aberration of chromosome.
CONCLUSIONS
The overall incidence of chromosomal aberration in amenorrhea was 27.7%. Cytogenetic screening is very important for the investigation of causes of the amenorrhea.

Keyword

Chromosome aberration; Amenorrhea; X chromosome
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