J Korean Soc Radiol.  2014 Feb;70(2):83-86. 10.3348/jksr.2014.70.2.83.

Multiple Solid Pilocytic Astrocytomas in Cerebellum with Neurofibromatosis Type I: A Case Report

  • 1Department of Radiology, Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital, Wonju, Korea. kim0328@yonsei.ac.kr


Pilocytic astrocytoma usually has a classic imaging manifestation of a solitary, cyst-like mass with a strong contrast-enhancing mural nodule. There is only one published report so far of multiple solid and cyst type pilocytic astrocytomas in the cerebellum in neurofibromatosis type 1 (NF1) patient from the United States in 2007. We report a case of pilocytic astrocytoma presenting with only solid, multiple pilocytic astrocytomas in the cerebellum in NF1 patient.

MeSH Terms

Neurofibromatosis 1*
United States


  • Fig. 1 A 10-year-old male with a known history of neurofibromatosis type 1. A. Axial CT scan of the brain with brain window image reveals bilateral low density with central iso or high density in both cerebellum (arrows). B-E. Axial T1 weighted (B), T2 weighted (C), T2 fluid attenuated inversion recovery (D) and post-contrast enhanced T1 weighted images (E) of the MRI of the brain show multiple well-demarcated nodular contrast enhancing solid lesions in both cerebellar hemisphere with heterogenous low signal intensity on the T1 weighted images, high signal intensity on the T2 weighted images (arrows). Perielesional vasogenic edema was surrounding these lesions without causing obstructive hydrocephalus. F. Axial T2 weighted images of the MRI of the brain shows multiple high signal intensity involves both basal ganglia, posterior limb of right internal capsule (arrows). G. Photomicrograph of the surgical specimen shows loose component of the tumor. Eosinophilic granulor bodies (arrowhead) and multifocal areas of myxoid change (arrow) are seen in the hematoxylin-eosin stain (× 200). Cytologically, glial fibrilary acidic protein (+) glial cells with elongated nuclei were seen.


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