Korean J Pathol.  2010 Jun;44(3):330-332.

Acute Appendicitis Associated with Aspergillosis in a Leukemia Patient: A Case Report

Affiliations
  • 1Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • 2Department of Pathology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea. ymkpath@uuh.ulsan.kr
  • 3Department of Surgery, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.

Abstract

Herein we describe a rare case of acute appendicitis associated with localized aspergillosis in an 8-year-old boy with acute lymphoblastic leukemia. During chemotherapy, the patient complained of mild abdominal pain in the peri-umbilical area and displayed an increased C-reactive protein level. Abdominal ultrasonography disclosed appendicitis and consequently an appendectomy was done. Histologically, acute appendicitis and Aspergillus hyphae were identified in the lumen and necrotic mucosa. However, there was no evidence of systemic aspergillosis. While aspergillosis is a common fungal infection in immunocompromised patients treated with chemotherapy, acute appendicitis associated with localized aspergillosis without systemic infection is a very rare occurrence.

Keyword

Appendicitis; Aspergillosis; Leukemia

MeSH Terms

Abdominal Pain
Appendectomy
Appendicitis
Aspergillosis
Aspergillus
C-Reactive Protein
Child
Humans
Hyphae
Immunocompromised Host
Leukemia
Mucous Membrane
Precursor Cell Lymphoblastic Leukemia-Lymphoma
C-Reactive Protein
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