J Korean Radiol Soc.  2000 Sep;43(3):291-297. 10.3348/jkrs.2000.43.3.291.

Deep Venous Thrombosis in the Lower Extremity: Catheter-Directed Thrombolysis

• Roh BS
• So BJ
• Kim EA
• Park KH
• Yoon KH
• Juhng SK
• Won JJ

• KMID: 1832712
• DOI: http://doi.org/10.3348/jkrs.2000.43.3.291

Abstract

PURPOSE: To evaluate the efficacy of catheter-directed thrombolysis in treating symptomatic deep venous thrombosis (DVT) in lower limbs.
MATERIALS AND METHODS
Twenty-six consecutive patients (16 male and 10 female; mean age, 55 years) with lower extremity DVT underwent thrombolytic therapy. The duration of symptoms was 1 -90 (mean, 17) days: 20 days or less in 16 cases (acute DVT) and less than 20 days in ten (chronic DVT). Catheter-directed infusions of urokinase were administered via ipsilateral popliteal veins, and angioplasty or stent placement was performed after the thrombolytic procedure. Oral medication of warfarin continued for six months, and for the evaluation of venous patency, follow-up ultrasonography was performed. The total dose of infused urokinase was 1,750,000 -10,000,000 (mean 4, 84,000) IU, and the total procedural time was 25 -115 (mean, 64) hours.
RESULTS
Lysis was complete in 16 cases (62%, all acute DVT), partial in five (19%, chronic DVT), and failed in five (19%, chronic DVT). Eight patients with venous stenosis and two with occlusion were treated by means of angioplasty (n=4) or Wallstent placement (n=6). Minor bleeding occurred in six cases and major complications in two (one of pulmonary embolism, and one of multiorgan failure).
CONCLUSION
Catheter-directed thrombolysis with urokinase is effective for the treatment of DVT in lower limbs.

Keyword

Thrombosis, venous; Thrombolysis; Veins, stenosis or obstruction; Veins, interventional procedures

MeSH Terms

Angioplasty
Constriction, Pathologic
Female
Follow-Up Studies
Hemorrhage
Humans
Lower Extremity*
Male
Popliteal Vein
Pulmonary Embolism
Stents
Thrombolytic Therapy
Ultrasonography
Urokinase-Type Plasminogen Activator
Venous Thrombosis*
Warfarin
Urokinase-Type Plasminogen Activator
Warfarin