Clin Pediatr Hematol Oncol.  2013 Oct;20(2):112-115.

Pneumatosis Intestinalis Developed due to CMV Infection in a Pediatric Severe Aplastic Anemia Patient after Hematopoietic Stem Cell Transplantation

• Seon MG
• Jung HJ
• Noh OK
• Park JE

Abstract

A 10-year old girl diagnosed as severe aplastic anemia was transplanted with peripheral stem cells from a CMV seropositive full matched unrelated donor. The conditioning regimen consisted of busulfan, fludarabine, and anti-thymocyte globulin (ATG). At D+114, abdominal pain, fever, and blood-tinged watery diarrhea developed. At D+116, pneumatosis intestinalis (PI) was detected on simple abdominal X-ray and computed tomography (CT). Ganciclovir was started intravenously because CMV antigenemia was detected at D+117. Two days later, PI sign disappeared on simple abdominal X-ray, and hematochezia began to decrease. CMV antigenemia disappeared 10 days after starting ganciclovir. We describe a 10-year old girl with severe aplastic anemia who developed PI in the presence of CMV infection and gastro-intestinal graft-versus-host-disease (GVHD) after allogeneic stem cell transplantation and was treated successfully with ganciclovir.

Keyword

Pneumatosis intestinalis; CMV infection; Graft-versus-host disease; Hematopoietic stem cell transplantation

MeSH Terms

Abdominal Pain
Anemia, Aplastic*
Antilymphocyte Serum
Busulfan
Diarrhea
Female
Fever
Ganciclovir
Gastrointestinal Hemorrhage
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation*
Hematopoietic Stem Cells*
Humans
Stem Cell Transplantation
Stem Cells
Unrelated Donors
Vidarabine
Antilymphocyte Serum
Busulfan
Ganciclovir
Vidarabine