Allergy Asthma Respir Dis.  2014 Nov;2(5):352-357. 10.4168/aard.2014.2.5.352.

Clinical features of delayed contrast media hypersensitivity

• Kim MH
• Lee SY
• Lee SE
• Kim MY
• Jo EJ
• Park CM
• Lee W
• Cho SH
• Kang HR

• KMID: 1803542
• DOI: http://doi.org/10.4168/aard.2014.2.5.352

Abstract

PURPOSE
Delayed hypersensitivity reaction can occur in a couple of hours to several days after injection of iodine-based contrast media (ICM). ICM-related delayed type hypersensitivity is not common but increasing as rapid growth of ICM use. Nevertheless, objective data on delayed type hypersensitivity are still scarce worldwide including Korea. This study was performed to investigate the clinical features of ICM-induced delayed hypersensitivity in Korean patients.
METHODS
We retrospectively reviewed the electronic medical records of patients diagnosed with delayed hypersensitivity to ICM from January 2009 to December 2012 at Seoul National University Hospital and analyzed the data to identify the clinical characteristics of these patients.
RESULTS
A total of 44 cases were diagnosed as delayed-type hypersensitivity to ICM. The mean age was 54 years, and 70.5% were female. The mean number of previous ICM exposure was 3.8, and skin reactions were the most common symptoms. In 45% of patients, hypersensitivity reaction developed on the first exposure to ICM. Among the 27 patients exposed to ICM again, hypersensitivity reactions recurred in only 4 patients (14.8%). There was no difference of recurrence rate according to the use of premedication or the change in ICM.
CONCLUSION
In this study, we observed a female predominance and a low recurrence rate in delayed hypersensitivity to ICM. Premedication and ICM change was not effective in preventing recurrence of delayed type reactions.

Keyword

Contrast media; Delayed hypersensitivity; Recurrence

MeSH Terms

Contrast Media*
Electronic Health Records
Female
Humans
Hypersensitivity*
Hypersensitivity, Delayed
Korea
Premedication
Recurrence
Retrospective Studies
Seoul
Skin
Contrast Media

Figure

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  Fig. 1 Number of patients according to their symptoms onset time.

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  Fig. 2 Number of previous contrast exposure among patients with delayed contrast media hypersensitivity.

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  Fig. 3 Management and follow-up results after delayed contrast media hypersensitivity. RCM, radiocontrast media.

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