J Korean Med Sci.  2010 Apr;25(4):546-551. 10.3346/jkms.2010.25.4.546.

Long Term Follow-up Results of External Beam Radiotherapy as Primary Treatment for Retinoblastoma

• Choi SY
• Kim MS
• Yoo S
• Cho C
• Ji Y
• Kim K
• Seo Y
• Park KD
• Lee J
• Lee TW

• KMID: 1792923
• DOI: http://doi.org/10.3346/jkms.2010.25.4.546

Abstract

The authors reviewed their experiences of external beam radiotherapy (EBR) as an initial treatment in retinoblastoma patients to determine its long-term effect on subsequent tumor control and complications. A total of 32 eyes in 25 patients that underwent EBR for retinoblastoma were reviewed retrospectively. The patients consisted of 21 boys and 4 girls of median age at treatment of 7.1 months. Radiation doses ranged from 35 to 59.4 Gy. The 10-yr ocular and patient survivals were 75.4% and 92.3%, respectively. Nine of the 32 eyes progressed; 7 of these were enucleated and 2 were salvaged by focal treatment. According to the Reese-Ellsworth classification, 4 of 5 eyes of Group II, 13 of 16 Group III eyes, 2 of 4 Group IV eyes, and 5 of 7 Group V eyes were retained, and of the 32 eyes, 13 had visual acuity better than 20/200. Eleven patients experienced a radiation-induced complication. No patient developed a second malignancy during follow-up. Despite the limited number of patients enrolled, EBR may provide a mean of preserving eyeball and vision for some advanced lesions.

Keyword

Retinoblastoma; External Beam Radiotherapy; Complication

MeSH Terms

Child
Child, Preschool
Eye Enucleation
Female
Humans
Infant
Korea
Male
Radiotherapy/*methods
Radiotherapy Dosage
Retinal Neoplasms/*radiotherapy
Retinoblastoma/*radiotherapy
Retrospective Studies
Survival Rate
Treatment Outcome

Figure

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  Fig. 1 Overall and ocular survival.

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  Fig. 2 Midfacial hypoplasia and microophthalmia. (A) Midfacial hypoplasia is noted on the right. (B) CT scan shows smaller eyeball and orbit on the left.

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