J Korean Med Sci.  2004 Jun;19(3):462-465. 10.3346/jkms.2004.19.3.462.

A Hybrid Carcinoma of Epithelial-Myoepithelial Carcinoma and Adenoid Cystic Carcinoma in Maxillary Sinus

• Woo JS
• Kwon SY
• Jung KY
• Kim I

• KMID: 1786829
• DOI: http://doi.org/10.3346/jkms.2004.19.3.462

Abstract

Hybrid carcinoma of the salivary gland is a very rare entity that has been described only in the parotid and palate. The occurrence of a hybrid carcinoma of maxillary sinus has not been reported. The diagnosis of hybrid carcinoma is important particularly when the components of tumor have different biologic behaviors. Diagnosis and treatment require a high index of suspicion, especially when the tumor is an epithelial-myoepithelial carcinoma, pathological effort to look for a more aggressive accompanying tumor, and proper oncologic treatment. We describe a case of 26-yrold woman with a hybrid carcinoma composed of epithelial-myoepithelial carcinoma with an adenoid cystic carcinoma component (cribriform pattern) in the right maxillary sinus with a brief review of the relevant literature.

Keyword

Hybrid; Carcinoma; Maxillary Sinus Neoplasms; Carcinoma, Adenoid Cystic

MeSH Terms

Adult
Carcinoma/*diagnosis/pathology
Carcinoma, Adenoid Cystic/*diagnosis/pathology
Female
Human
Immunohistochemistry
Maxillary Sinus Neoplasms/*diagnosis/pathology
Neoplasm Metastasis
Neoplasms, Glandular and Epithelial/*diagnosis/pathology
Neoplasms, Multiple Primary/*diagnosis/pathology
Prognosis
Recurrence
Treatment Outcome

Figure

• 

  Fig. 1 A CT scan showing a slightly enhanced, soft tissue mass filling the right anterior nasal cavity and the maxillary sinus, extending to the nasal septum and the right nasal dorsum.

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  Fig. 2 An area of typical adenoid cystic carcinoma with a cribriform pattern (H-E stain, ×40 (A), ×200 (B)).

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  Fig. 3 An area of epithelial-myoepithelial carcinoma composed of ductular structures surrounded by clear myoepithelial cells (H-E stain, ×40 (A), ×200 (B)).

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  Fig. 4 Immunohistochemical staining for smooth muscle actin (SMA) shows cytoplasmic staining on the myoepithelial cells of epithelial-myoepithelial carcinoma (EMC)(A) and adenoid cystic carcinoma (ACC)(B). Ductal epithelial cells are highlighted by immunostaining for epithelial membrane antigen (EMA) and low molecular weight cytokeratin (CK) in both EMC and ACC (ABC stain, ×400).

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