Yonsei Med J.  2009 Feb;50(1):137-141. 10.3349/ymj.2009.50.1.137.

The Expression of Folate Sensitive Fragile Sites in Patients with Bipolar Disorder

• Demirhan O
• Tastemir D
• Sertdemir

• KMID: 1782979
• DOI: http://doi.org/10.3349/ymj.2009.50.1.137

Abstract

PURPOSE
Genetic factors are known to be important in the etiology of bipolar disorder (BD). The fragile sites (FSs) are a very interesting subject for the study of clinical disorders. The aim of this study was to evaluate fragile sites seen in patients with bipolar disorder and find a correlation between some fragile sites and bipolar disorder.
PATIENTS AND METHODS
The frequencies of folate sensitive FSs were compared in short-term whole blood cultures from bipolar patients and from normal individuals.
RESULTS
The rate of FS expression in the patients was considerably higher than in the controls (p < 0.001). Several chromosome regions including 1p36, 1q21, 1q32, 3p25, 7q22, 7q32, 11q23, 12q24, 13q32, 14q24, Xp22 and Xq26 were represented considerably more often in the patients than in the controls (p value between 0.001 to 0.036). Among these FSs, the sites 1p36, 1q21, 3p25, 7q22, 7q32, and 14q24 were not observed in other studies.
CONCLUSION
These regions can be the most active of hot spots in the genomes of bipolar patients, and may harbor important genes associated with BD.

Keyword

Bipolar disorder; cytogenetics; fragile sites; chromosome 1, 3, 7, 11, 12, 13, 14 and X

MeSH Terms

Adolescent
Adult
Bipolar Disorder/*genetics
Chromosome Fragile Sites/drug effects/*genetics
Chromosome Fragility/drug effects/*genetics
Chromosomes, Human/*genetics
Cytogenetics
Female
Folic Acid/pharmacology
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Young Adult

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