J Korean Med Sci.  2011 Feb;26(2):297-300. 10.3346/jkms.2011.26.2.297.

Catheter-related Candidemia Caused by Candida haemulonii in a Patient in Long-term Hospital Care

• Kim S
• Ko KS
• Moon SY
• Lee MS
• Lee MY
• Son JS

• KMID: 1782122
• DOI: http://doi.org/10.3346/jkms.2011.26.2.297

Abstract

Candida haemulonii, one of the non-albicans Candida species, is an emerging yeast pathogen that is known to be resistant to amphotericin B and other antifungal agents such as azoles. These anti-fungal agents have often been associated with clinical treatment failure, so no treatment regimen has been clearly established for invasive C. haemulonii infections. We investigated a catheter-related infection of C. haemulonii candidemia in an adult patient in long-term hospital care. In the early stages, the candidemia remained persistent despite treatment with fluconazole. However, after changing the antifungal agent to caspofungin, the candidemia was resolved. Fluconazole and amphotericin B are not reliable empirical antifungal agents for invasive C. haemulonii infections, as shown in previous case reports. An echinocandin such as caspofungin may be an appropriate empirical choice of antifungal agent for an invasive C. haemulonii infection.

Keyword

Candida haemulonii; Candidemia; Caspofungin; Echinocandins

MeSH Terms

Aged
Amphotericin B/therapeutic use
Antifungal Agents/therapeutic use
Candida/classification/isolation & purification/*pathogenicity
Candidiasis/drug therapy/*microbiology
Catheter-Related Infections/drug therapy/*microbiology
Echinocandins/therapeutic use
Fluconazole/therapeutic use
*Hospitals
Humans
*Long-Term Care
Male
Phylogeny

Figure

• 

  Fig. 1 Phylogenetic tree analysis of a large subunit (LSU) rRNA gene of isolated Candida sp., LYS-1.

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