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Korean J Lab Med.  2009 Feb;29(1):1-9. 10.3343/kjlm.2009.29.1.1.

Correct Use of Repeated Measures Analysis of Variance

Affiliations
  • 1Department of Statistics, College of Natural Sciences, Chonnam National University, Gwangju, Korea. espark02@chonnam.ac.kr
  • 2Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Abstract

In biomedical research, researchers frequently use statistical procedures such as the t-test, standard analysis of variance (ANOVA), or the repeated measures ANOVA to compare means between the groups of interest. There are frequently some misuses in applying these procedures since the conditions of the experiments or statistical assumptions necessary to apply these procedures are not fully taken into consideration. In this paper, we demonstrate the correct use of repeated measures ANOVA to prevent or minimize ethical or scientific problems due to its misuse. We also describe the appropriate use of multiple comparison tests for follow-up analysis in repeated measures ANOVA. Finally, we demonstrate the use of repeated measures ANOVA by using real data and the statistical software package SPSS (SPSS Inc., USA).

Keyword

Ethics; ANOVA; Repeated measures; Multiple comparison

MeSH Terms

*Analysis of Variance
Chemistry, Clinical
*Models, Statistical
Multivariate Analysis
Reproducibility of Results
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