Yonsei Med J.  2013 Jan;54(1):262-264. 10.3349/ymj.2013.54.1.262.

A Case of Immunoglobulin E Mediated Anaphylaxis to Levodropropizine

• Park KH
• Yun IS
• Choi SY
• Lee JH
• Hong CS
• Park JW

• KMID: 1776949
• DOI: http://doi.org/10.3349/ymj.2013.54.1.262

Abstract

We experienced a case of immunoglobulin E (IgE) mediated anaphylaxis to levodropropizine. The patient was an 18-year old Korean woman. After taking the common cold medication including acetaminophen, domperidone, and levodropropizine, skin rash, angioedema and anaphylaxis were developed immediately. As she was tolerable to acetaminophen alone, we thought the culprit agent was maybe a levodropropizine tablet. To confirm the culprit, she underwent skin prick test and oral drug provocation test with the suspected one. Finally we detected levodropropizine specific IgE and confirmed the specificity by inhibition enzyme-linked immunosorbent assay (ELISA).

Keyword

Levodropropizine; anaphylaxis; drug hypersensitivity

MeSH Terms

Adolescent
Anaphylaxis/*chemically induced/*immunology
Antitussive Agents/*adverse effects
Bronchial Provocation Tests
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin E/*immunology
Propylene Glycols/*adverse effects
Skin Tests
Antitussive Agents
Propylene Glycols
Immunoglobulin E

Figure

• 

  Fig. 1 (A) Level of levodropropizine-specific immunoglobulin (Ig) E in healthy controls and patient serum. Control serum 0.001 OD, patient serum 0.166 OD, respectively. (B) Inhibition ELISA using levodropropizine as the inhibitor. Levodropropizine showed dose-dependent inhibition pattern. At 0.1 M concentration, it completely inhibited the binding of specific IgE to levodropropizine-HSA conjugate. ODU, optical density unit; HSA, human serum albumin; ELISA, enzyme-linked immunosorbent assay.

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