Korean J Gastroenterol.  2012 Oct;60(4):258-261. 10.4166/kjg.2012.60.4.258.

A Case of Intraperitoneal Immunoglobulin G4-related Inflammatory Pseudotumor

  • 1Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. jbkim87@hallym.or.kr
  • 2Department of Pathology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.


The term inflammatory pseudotumor (IPT) has been used to describe inflammatory and fibrosing tumoral processes of an undetermined cause that may involve a variety of organ system. IgG4-related disease is a newly recognized fibroinflammatory condition characterized by IgG4-producing plasma cell expansion in affected organs and, often but not always, elevated serum IgG4 concentrations. IgG4-related IPTs, a subtype of IPT, are characterized by dense infiltration of IgG4-positive plasma cells and stromal fibrosis. The association between inflammatory pseudotumor and IgG4 was first reported with a regard to sclerosing pancreatitis. Despite there are many reports on intraperitoneal IPTs including both cellular and lymphoplasmacytic type, only a few cases have been confirmed to be IgG4-related. We experienced a case of intraperitoneal IgG4-related inflammatory pseudotumor in an 83-year-old woman presenting with epigastric pain and malaise. Surgical specimens revealed an IgG4-related inflammatory pseudotumor.


IgG4-related disease; Immunoglobulin G4; Inflammatory pseudotumor; Intraperitoneal tumor

MeSH Terms

Aged, 80 and over
C-Reactive Protein/analysis
Granuloma, Plasma Cell/*diagnosis/pathology/surgery
Immunoglobulin G/*blood
Plasma Cells/metabolism
Positron-Emission Tomography
Tomography, X-Ray Computed
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