Clin Endosc.  2016 Mar;49(2):197-201. 10.5946/ce.2015.074.

Immunoglobulin G4-Related Inflammatory Pseudotumor Presenting as a Solitary Mass in the Stomach

Affiliations
  • 1Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea. bongsul@hanmail.net

Abstract

Immunoglobulin G4 (IgG4)-related disease (IgG4RD) is a relatively recently recognized entity that is histopathologically characterized by an extensive infiltration of lymphocytes and IgG4-positive plasma cells with dense fibrosis. IgG4RD is now known to affect any organ system, and a few cases of gastrointestinal lesions have also been reported. However, solitary IgG4RD of the stomach is still very rare. Furthermore, as it can mimic malignant conditions, it is important to recognize this disease to avoid unnecessary surgery. Herein, we present a case of IgG4RD presenting as an isolated subepithelial mass in the stomach.

Keyword

Immunoglobulin G4-related sclerosing disease; Pseudotumor; Stomach

MeSH Terms

Fibrosis
Granuloma, Plasma Cell*
Immunoglobulins*
Lymphocytes
Plasma Cells
Stomach*
Unnecessary Procedures
Immunoglobulins

Figure

  • Fig. 1. Abdominal computed tomography images showing multiple cysts in both kidneys (A) and an intramural enhancing mass in the gastric fundus (B).

  • Fig. 2. Endoscopic findings. (A) Helicobacter pylori-positive lymphofollicular gastritis. (B) An approximately 4-cm, hard, fixed subepithelial mass with distinct ulceration on the surface, located in the fundus. (C) Endoscopic ultrasonography image showing a 3.4×1.6 cm homogeneous hypoechoic mass located in the muscularis mucosa up to the submucosa.

  • Fig. 3. Gross findings after formalin fixation. (A, B) On the specimen section, a well-defined homogeneous gray-white solid submucosal mass (asterisks) is identifiable. The gastric mucosa (arrows) is unremarkable.

  • Fig. 4. Pathologic findings. (A) Dense fibrosis admixed with inflammatory cells composing the submucosal mass that extends to the subserosa (asterisk, mucosa; arrowhead, submucosa; circle, muscularis propria; H&E stain, ×12.5). (B) Bland-looking spindle cells arranged in a storiform pattern (H&E, ×200). (C) Fibroblastic cells admixed with dense lymphoplasmacytic cells (H&E, ×400). (D) Immunoglobulin G (IgG) immunohistochemical staining showing increased numbers of IgG-positive plasma cells in the stroma (402/high power field [HPF], ×200). (E) IgG4 immunohistochemical staining revealing increased numbers of IgG4-positive plasma cell infiltration (102/HPF, ×200); the ratio of IgG4+/IgG+ plasma cells was 25.3%.


Cited by  2 articles

IgG4-related Disease in the Stomach which Was Confused with Gastrointestinal Stromal Tumor (GIST): Two Case Reports and Review of the Literature
Ho Seok Seo, Yoon Ju Jung, Cho Hyun Park, Kyo Young Song, Eun Sun Jung
J Gastric Cancer. 2018;18(1):99-107.    doi: 10.5230/jgc.2018.18.e8.

Gastric IgG4-related disease presenting as a mass lesion and masquerading as a gastrointestinal stromal tumor
Banumathi Ramakrishna, Rohan Yewale, Kavita Vijayakumar, Patta Radhakrishna, Balakrishnan Siddartha Ramakrishna
J Pathol Transl Med. 2020;54(3):258-262.    doi: 10.4132/jptm.2020.02.10.


Reference

1. Umehara H, Okazaki K, Masaki Y, et al. Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011. Mod Rheumatol. 2012; 22:21–30.
2. Stone JH, Zen Y, Deshpande V. IgG4-related disease. N Engl J Med. 2012; 366:539–551.
Article
3. Kamisawa T, Funata N, Hayashi Y, et al. A new clinicopathological entity of IgG4-related autoimmune disease. J Gastroenterol. 2003; 38:982–984.
Article
4. Kanno A, Satoh K, Kimura K, et al. Autoimmune pancreatitis with hepatic inflammatory pseudotumor. Pancreas. 2005; 31:420–423.
Article
5. Zen Y, Kitagawa S, Minato H, et al. IgG4-positive plasma cells in inflammatory pseudotumor (plasma cell granuloma) of the lung. Hum Pathol. 2005; 36:710–717.
Article
6. Cha DH, Choi CW, Kim S, et al. An IgG4-related inflammatory pseudotumor of the greater omentum. Korean J Med. 2013; 84:400–404.
Article
7. Rollins KE, Mehta SP, O’Donovan M, Safranek PM. Gastric IgG4-related autoimmune fibrosclerosing pseudotumour: a novel location. ISRN Gastroenterol. 2011; 2011:873087.
Article
8. Chetty R, Serra S, Gauchotte G, Märkl B, Agaimy A. Sclerosing nodular lesions of the gastrointestinal tract containing large numbers of IgG4 plasma cells. Pathology. 2011; 43:31–35.
Article
9. Na KY, Sung JY, Jang JY, et al. Gastric nodular lesion caused by IgG4-related disease. Pathol Int. 2012; 62:716–718.
Article
10. Kim do H, Kim J, Park do H, et al. Immunoglobulin G4-related inflammatory pseudotumor of the stomach. Gastrointest Endosc. 2012; 76:451–452.
11. Fujita T, Ando T, Sakakibara M, Hosoda W, Goto H. Refractory gastric ulcer with abundant IgG4-positive plasma cell infiltration: a case report. World J Gastroenterol. 2010; 16:2183–2186.
Article
12. Bateman AC, Sommerlad M, Underwood TJ. Chronic gastric ulceration: a novel manifestation of IgG4-related disease? J Clin Pathol. 2012; 65:569–570.
Article
Full Text Links
  • CE
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2022 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr