Korean J Gastroenterol.
2005 Mar;45(3):195-200.
Two Cases of Metronidazole-induced Encephalopathy
- Affiliations
-
- 1Departments of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea. HJLEE@med.yu.ac.kr
- 2Departments of Radiology, Yeungnam University College of Medicine, Daegu, Korea.
Abstract
- Metronidazole is a 5-nitroimidazole compound known as an antimicrobial agent widely used for the treatment of protozoal infection, anaerobic infection, Helicobacter pylori infection and hepatic encephalopathy. It may produce a number of neurologic side effects including peripheral neuropathy, seizure, encephalopathy, ataxic gait and dysarthritic speech. There have been ten or more reports of metronidazole-induced encephalopathy in the literatures including a few reports of brain imaging changes by magnetic resonance images (MRI). However, none of the case of metronidazole-induced encephalopathy in patients with hepatic encephalopathy has been reported yet. Recently, we experienced two cases of metronidazole-induced encephalopathy in patients with liver cirrhosis caused by chronic hepatitis B, which were diagnosed by brain MRI and MR spectroscopy. In this report, we present 2 cases of metronidazole-induced encephalopathy with MR imaging and MR spectroscopic changes including follow- up imaging performed after the discontinuation of the metronidazole with a review of the literatures.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Metronidazole Induced Encephalopathy in a Patient with Brain Abscess
- Oculogyric Crisis Due to Metronidazole Toxic Encephalopathy
- A Case of Metronidazole-Induced Encephalopathy: Atypical Involvement of the Brain on MRI
- Metronidazole-induced encephalopathy in a patient with liver cirrhosis
- A case of metronidazole induced encephalopathy in a cirrhotic patient
