Korean J Anesthesiol.  2010 May;58(5):440-445. 10.4097/kjae.2010.58.5.440.

The effect of ketamine on the incidence of emergence agitation in children undergoing tonsillectomy and adenoidectomy under sevoflurane general anesthesia

• Lee YS
• Kim WY
• Choi JH
• Son JH
• Kim JH
• Park YC

• KMID: 1766260
• DOI: http://doi.org/10.4097/kjae.2010.58.5.440

Abstract

BACKGROUND
The rapid emergence and recovery from general anesthesia afforded by sevoflurane is associated with a high incidence of emergence agitation in children. Small doses of ketamine reduce the incidence of emergence agitation. This study compared the effects of ketamine 0.25 mg/kg and 0.5 mg/kg on emergence agitation and postoperative pain.
METHODS
The effects of added intravenous ketamine were evaluated in 93 children, ASA I-II, 2-14 years old, undergoing an adenotonsillectomy. The patients were allocated randomly to one of three groups receiving saline (group C), ketamine 0.25 mg/kg (group K0.25) or ketamine 0.5 mg/kg (group K0.5). The children in each group were administered the study drugs 10 minutes before the end of surgery. The recovery characteristics, including the time to extubation, delivery time from the PACU, postoperative nausea and vomiting, agitation and pain were assessed.
RESULTS
There were no significant differences in the extubation time, delivery time and postoperative nausea and vomiting between the three groups. There were significant differences in modified CHEOPS (Children's Hospital of Eastern Ontario Pain Scale) between the three groups. The incidence of emergence agitation was low in the K0.25 and K0.5 groups compared to the control group. However, there was no significant difference between the K0.25 and K0.5 groups.
CONCLUSIONS
There was no significant difference in the incidence of emergence agitation between K0.25 and K0.5 groups. However, K0.5 group showed a lower pain score than K0.25 group.

Keyword

Emergence agitation; Ketamine; Sevoflurane

MeSH Terms

Adenoidectomy
Anesthesia, General
Child
Dihydroergotamine
Humans
Incidence
Ketamine
Methyl Ethers
Ontario
Pain, Postoperative
Postoperative Nausea and Vomiting
Tonsillectomy
Dihydroergotamine
Ketamine
Methyl Ethers