Korean J Anesthesiol.  2010 May;58(5):435-439. 10.4097/kjae.2010.58.5.435.

Pain reduction on injection of microemulsion propofol via combination of remifentanil and lidocaine

• Han YK
• Jeong CW
• Lee HG

• KMID: 1766259
• DOI: http://doi.org/10.4097/kjae.2010.58.5.435

Abstract

BACKGROUND
Microemulsion propofol produces more frequent and severe pain upon injection than lipid emulsion propofol. This study examined the analgesic effect of lidocaine-premixed microemulsion propofol in patients pretreated with remifentanil. The induction of anesthesia with this combination was compared with microemulsion propofol accompanied with either remifentanil or lidocaine.
METHODS
One hundred twenty patients aged between 20-65 years old were allocated randomly into one of three groups (n = 40, in each). The patients in the remifentanil group received remifentanil 0.5 microgram/kg IV for 30 seconds before a microemulsion propofol injection. The patients in the lidocaine group received propofol 2 mg/kg premixed with 40 mg lidocaine over a 60 second period. The patients in the combination group received both remifentanil and lidocaine.
RESULTS
There was a significantly lower incidence of microemulsion propofol injection pain (severity 2 or more) in the combination group (12.5%) than in the remifentanil and lidocaine groups (90% and 65%, respectively, P < 0.05). The incidence of moderate pain disappeared completely in the combination group (0%) compared to that in the remifentanil and lidocaine group (32.5% and 20%, respectively, P < 0.05). Severe pain did not appear in any of the three groups. There were no complications on the injection site in the lidocaine alone and combination groups.
CONCLUSIONS
The combination of microemulsion propofol premixed with lidocaine after a pretreatment with remifentanil was more effective in reducing the incidence of pain upon the injection of microemulsion propofol than either treatment alone.

Keyword

Intravenous anesthetics; Lidocaine; Microemulsion propofol; Pain; Remifentanil

MeSH Terms

Aged
Anesthesia
Anesthetics, Intravenous
Humans
Incidence
Lidocaine
Piperidines
Propofol
Anesthetics, Intravenous
Lidocaine
Piperidines
Propofol