Clin Mol Hepatol.  2012 Jun;18(2):229-234. 10.3350/cmh.2012.18.2.229.

Concurrent hepatic adenomatoid tumor and hepatic hemangioma: a case report

Affiliations
  • 1Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • 2Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. esyu@amc.seoul.kr
  • 3Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Abstract

A 45-year-old male with alleged asymptomatic hepatic hemangioma of 4 years duration had right upper-quadrant pain and was referred to a tertiary hospital. Computed tomography and magnetic resonance imaging scans revealed a hypervascular mass of about 7 cm containing intratumoral multilobulated cysts. A preoperative liver biopsy was performed, but this failed to provide a definitive diagnosis. The patient underwent a partial hepatectomy of segments IV and VIII. The histologic findings revealed multifocal proliferation of flattened or cuboidal epithelioid cells and a highly vascular edematous stroma. Immunohistochemistry findings demonstrated that the epithelioid tumor cells were positive for cytokeratin (AE1/AE3), vimentin, calretinin, and cytokeratin 5/6, and were focally positive for CD10, and negative for WT1 and CD34, all of which support their mesothelial origin. Immunohistochemistry for a mesothelial marker should be performed for determining the presence of an adenomatoid tumor when benign epithelioid cells are seen.

Keyword

Adenomatoid tumor; Liver; Hemangioma

MeSH Terms

Adenomatoid Tumor/*diagnosis/pathology/surgery
Calcium-Binding Protein, Vitamin D-Dependent/metabolism
Hemangioma/*diagnosis/pathology/surgery
Hepatectomy
Humans
Keratins/metabolism
Liver Neoplasms/*diagnosis/pathology/surgery
Magnetic Resonance Imaging
Male
Middle Aged
Neprilysin/metabolism
Tomography, X-Ray Computed
Vimentin/metabolism
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