Int J Oral Biol.  2014 Jun;39(2):57-63.

Cariogenic Activity in Saliva of Korean Head and Neck Cancer Patients

Affiliations
  • 1Department of dentistry, Chonnam National University Hwasun Hospital, Hwasun, 519-763, Korea. tarazeds@hanmail.net
  • 2Dental Science Research Institute, Chonnam National University, Gwangju, 500-757, Korea.
  • 3Department of Dental Education, School of Dentistry, Chonnam National University, Gwangju, 500-757, Korea.
  • 4Department of Biomedical research institute, Chonnam National University Hwasun Hospital, Hwasun, 519-763, Korea.
  • 5Department of Forensic Medicine, Chosun University, School of Medicine, Gwangju, 501-759, Korea.
  • 6Department of Microbiology, Chonnam National University Medical School, Gwangju, 501-746, Korea.
  • 7Department of Clinical Laboratory Science, Seonam University, Gwangju, 502-157, Korea.
  • 8Research Center for Biomineralization Disorder, Chonnam National University, Gwangju, 500-757, Korea.
  • 9Department of Dental Hygiene, Gwangju Health University, Gwangju, 506-701, Korea.

Abstract

The purpose of this study is to evaluate salivary flow rate, salivary pH, and cariogenic activity using unstimulated saliva of the head and neck cancer patients. Twenty three cancer patients (19 males, 4 females) who had undergone chemotherapy and radiation therapy and twenty four healthy volunteers (14 males, 10 females) as a control were included. Salivary flow rate, salivary pH, and cariogenic activity using unstimulated saliva were examined. Compared to saliva of the control group, salivary flow rate (p<0.001) and salivary pH (p<0.001) were significantly lower in head and neck cancer patients. The colony counts of Lactobacilli was higher in head and neck cancer patients (p<0.05) than in control group. These salivary factors and cariogenic activity can increase the prevalence of dental caries in head and neck cancer patients.

Keyword

head and neck cancer patients; cariogenic activity; salivary pH; salivary flow rate
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