Korean J Otorhinolaryngol-Head Neck Surg.  2011 Nov;54(11):741-745. 10.3342/kjorl-hns.2011.54.11.741.

Salivary Diagnostics

Affiliations
  • 1Department of Otolaryngology-Head and Neck Surgery, Catholic University of Daegu School of Medicine, Daegu, Korea. doctorjkkim@cu.ac.kr

Abstract

Saliva contains various sources of biomarkers like protein, mRNA, microRNA, metabolites and microbiota that could be considered as diagnostic alphabets. Collection of saliva is safe, easy, and non-invasive for both patients and medical workers. For the past 20 years, salivary diagnostics have been developed to monitor oral diseases. Recently, salivary diagnostics have extended the range of application from oral cavity to systemic sites such as pancreatic cancer and diabetes. Establishment of definitive salivary biomarkers for different diseases and development of accurate, easy-to-use and portable detection devices are required for the real clinical application of salivary diagnostics in the future medical practice.

Keyword

Saliva; Biomarkers; Diagnosis; Oral cancer

MeSH Terms

Biomarkers
Humans
Metagenome
MicroRNAs
Mouth
Mouth Neoplasms
Organothiophosphorus Compounds
Pancreatic Neoplasms
RNA, Messenger
Saliva
MicroRNAs
Organothiophosphorus Compounds
RNA, Messenger
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