J Korean Med Sci.  2001 Dec;16(Suppl):S66-S69. 10.3346/jkms.2001.16.S.S66.

Cancer Chemoprevention by Ginseng in Mouse Liver and Other Organs

• Nishino H
• Tokuda H
• Ii T
• Takemura M
• Kuchide M
• Kanazawa M
• Mou XY
• Bu P
• Takayasu J
• Onozuka M
• Masuda M
• Satomi Y
• Konoshima
• Kishi N
• Baba M
• Okada Y
• Okuyama T

• KMID: 1721177
• DOI: http://doi.org/10.3346/jkms.2001.16.S.S66

Abstract

Oral administration of red ginseng extracts (1% in diet for 40 weeks) resulted in the significant suppression of spontaneous liver tumor formation in C3H/He male mice. Average number of tumors per mouse in control group was 1.06, while that in red ginseng extracts-treated group was 0.33 (p<0.05). Incidence of liver tumor development was also lower in red ginseng extracts-treated group, although the difference from control group was not statistically significant. Anti-carcinogenic activity of white ginseng extracts, besides red ginseng extracts, was also investigated. In the present study, the administration of white ginseng extracts was proven to suppress tumor promoter-induced phenomena in vitro and in vivo. It is of interest that oral administration of the extracts of Ren-Shen-Yang- Rong-Tang, a white ginseng-containing Chinese medicinal prescription, resulted in the suppression of skin tumor promotion by 12-o-tetradecanoylphorbol-13-acetate in 7,12-dimethylbenz[a]anthracene-initiated CD-1 mice. These results suggest the usefulness of ginseng in the field of cancer prevention.

Keyword

Ginseng; Cancer Chemoprevention; Suppression of Tumor Promotion; Liver Neoplasms; Skin Neoplasms

MeSH Terms

Animal
Anticarcinogenic Agents/*pharmacology
Female
Liver Neoplasms, Experimental/*prevention & control
Male
Mice
Mice, Inbred C3H
*Panax
Plant Extracts/pharmacology
Plant Roots
Skin Neoplasms/*prevention & control