J Korean Med Sci.
2010 Aug;25(8):1182-1186. 10.3346/jkms.2010.25.8.1182.
A Nationwide Survey of Lymphangioleiomyomatosis in Korea: Recent Increase in Newly Diagnosed Patients
- Park HY
- Nam HS
- Chung MP
- Jeong SH
- Kim YJ
- Cha SI
- Kim YW
- Park JS
- Uh ST
- Park CS
- Park MS
- Moon JA
- Jung KS
- Jegal YJ
- Kim DS
- Song JW
- Yum HK
- Park YB
- Affiliations
-
- 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. mpchung@skku.edu
- 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Korea.
- 3Division of Pulmonary Medicine, Department of Internal Medicine, Gachon Medical School Gil Medical Center, Incheon, Korea.
- 4Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
- 5Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, and Lung Institute, Seoul National University Hospital, Seoul, Korea.
- 6Division of Respiration and Allergy Medicine, Soonchunhyang University Hospital, Seoul, Korea.
- 7Department of Internal Medicine, Bucheon Hospital, Soonchunhyang University School of Medicine, Bucheon, Korea.
- 8Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- 9Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
- 10Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- 11Department of Internal Medicine, Seoul Paik Hospital, Inje University, Seoul, Korea.
- 12Department of Internal Medicine, Hallym University College of Medicine, Kangdong Sacred Heart Hospital, Seoul, Korea.
- KMID: 1714040
- DOI: http://doi.org/10.3346/jkms.2010.25.8.1182
Abstract
- In 2007, the Korean Interstitial Lung Disease Society had collected clinical data of patients who have diagnosed as Lymphangioleiomyomatosis (LAM) since 1990 through nationwide survey, which showed that LAM patients had increased sharply after 2004. The present study was performed to show the clinical features of Korean patients with LAM, and to establish the reason for the recent increase in the diagnosis. All 63 patients were women and the mean age at diagnosis was 36 yr. The most common presenting symptom was dyspnea and 8 patients had tuberous sclerosis complex. The survival rate at 5 yr after diagnosis was 84%. Compared with patients diagnosed after 2004 (n=34), the patients diagnosed before 2004 (n=29) complained with dyspnea more (P=0.016) and had lower FEV1% predicted (P=0.003), and DLco% predicted (P=0.042). The higher proportion of patients diagnosed after 2004 showed the normal chest radiography, and they were detected by routine chest CT screening (P=0.016). This study showed that clinical features of Korean patients with LAM were not different from those reported elsewhere. It is concluded that the reason for the increase of newly diagnosed patients is the result of increase in detection of the early stage LAM by the widespread use of chest CT screening.
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