Korean J Dermatol.  1982 Aug;20(4):525-531.

The Effect of H1 and H2 Antihistaminics on Dermographism

• Kim KU
• Lee CJ

Abstract

This study was designed to evaluate the therapeutic effect of H2 and H2 antihistaminics on dermographism. Twenty four patients with dermographism were allocated on a random to one of the following 3 treatment regimens. A) chlorphenirarnine and cimetidine (H1+H1) B) chlorpheniramine alone (H>) C) cimetidine alone (H) The patients cutaneous response to the dermographometer was assessed at weekly intervals for four weeks. The results were as follows: 1. The combinded treatment with chlorpheniramine and cimetidine was significantly more effective in inhibiting wheal and flare than the cimetidine alone (wheal p<0.01, flare p<0.02). 2. Following comparisions were not statistically significant: chlorpheniramine+ cimetidine vs chlorpheniramine (p>0. 05), chlorpbeniramine alone vs cimetidine alone(p>0.05). 3. Main side effects were drowsiness (3 cases) and mild gastric disturbance (2 cases) on hlorpheniramine alone.

MeSH Terms

Chlorpheniramine
Cimetidine
Histamine H2 Antagonists*
Humans
Sleep Stages
Chlorpheniramine
Cimetidine
Histamine H2 Antagonists