Korean J Dermatol.  1981 Aug;19(4):533-539.

A Case of Eosinophilic Leukemia

• Lim CU
• Yu HJ
• Lee YS

Abstract

Eosinophilic leukemia is a rare variant of granulocytic leukemia. It has distinct clinical features to involve central nervous system, heart, lung and skin more frequently than other leukemia and laboratory findings to reveal persistent eosinophilia with immature tendency, leukocytosis, anernia, thrombocytopenia and usually negative philadelphia chromosome in cytogenetic study. We describe a 33 year-old male patient who has suffered from generalizid weakness exertional dyspnea and has had well defined, hen eggs ized, oval shaped and non-in-durated ulcerative lesions on the right thigh since about 4 months prior to admission. The laboratory findings were persistent leukocytosis, eosinophilia and immature tendency in peripheral blood, nearly 100% cellularity and eosinophilic tendency (70%) in bone marrow aspiration and biopsy, and negative philadelphia chromosome in cytogenetic study. A biopsy specimen from ulcer margin showed relatively intact epidermis and heavy cellular infiltration composed of eosinophilic cytoplasm, dark and indented nucleus in entire dermis. Normal appearing skin also revealed same cellular infiltration in dermis with perivascular and periadnexal pattern.

MeSH Terms

Adult
Biopsy
Bone Marrow
Central Nervous System
Cytogenetics
Cytoplasm
Dermis
Dyspnea
Eggs
Eosinophilia
Eosinophils*
Epidermis
Heart
Humans
Hypereosinophilic Syndrome*
Leukemia
Leukemia, Myeloid
Leukocytosis
Lung
Male
Ovum
Philadelphia Chromosome
Skin
Thigh
Thrombocytopenia
Ulcer