Korean J Dermatol.
1980 Feb;18(1):93-99.
Two Cases of Multicentric Pigmented Bowen's Disease
Abstract
- Bowen's disease may be defined as an intraepidermal squamous cell carcinoma of the skin whieh puraues a slow, relatively benign course but may progress into invasive carcinoma. We have experienced two female patients who had well demarcated, multicentric, brown to black colored flat-topped papules on the vulva with histopathologic features of intraepidermal squamous cell carcinoma but showed entireIy different clinicaI appearance from Bowen's disease. For differentiation from extramammary Paget's disease, PAS stain and mucicarmine stain were done but not reacted to them, Both cases were diagnosed as multicentric pigmented Bowen's disease, and in case 2, regression occured after local appIication of 5-fluorouracil cream. A conservative approach to managment of these lesions is suggested. We have experienced peculiar entities and literatures were reviewed.
