Korean J Dermatol.  1978 Jun;16(3):243-249.

A Case fo Disseminated Malignant Melanoma Arising From Pigmented Nevus

• Han JY
• Kook HI

Abstract

Malignant melanoma is a tumor arising within the melanocyte system of the skin, eyes and juxtacutaneous mucous membrane. Tbrough the lymphatic channel developed early metastasis and regional lymphade- nopzthy developed. Malignant melanoma may arise on apparently normal skin, in a junction nevua, rareh in a compound nevus and extremeIy rarely in an intradermaI nevus and 20% of total incidence of malignant melanoma are preceded by a nevocellular nevus. A 41 year-old male patient who had multiple, pea to walnut sized, black colored. nodules developing on entire body visited our Dermto. dept. About one year ago, solitary black colored nodule arose from preexisting pigmented nevus which had been from 20 yrs ago on Rt. ant. axillary area and then nodule remcved by wide exeision and regional lymphadenectomy at a Hosp. 2 months after surgical operation, multiple pea to walnut sized, black colored nodules has developed on entire body. There was no lymphadenopathy on entire body. In H-E & Fontana-Masson stain, numerous bizzarre large cells with hyperchromatic variable sized melanin pigments are seen in the dermis and subcutaneous tissues Mitotic figutes are present. Diagnosis was confirmed by the clinical and histological feature. The patient was treated with BCG waccination(4*10^6-8*10^6 live organisms weekly) by altemately intralesional inj, on the lesion and subcuraneous inj. on both shoulder during 6wks and has been in follow-up.

MeSH Terms

Adult
Ants
Dermis
Diagnosis
Follow-Up Studies
Humans
Incidence
Juglans
Lymph Node Excision
Lymphatic Diseases
Male
Melanins
Melanocytes
Melanoma*
Mucous Membrane
Mycobacterium bovis
Neoplasm Metastasis
Nevus
Nevus, Pigmented*
Peas
Shoulder
Skin
Subcutaneous Tissue
Melanins