J Korean Neurol Assoc.  1996 Dec;14(4):1007-1017.

3 Cases of Mononeuropathy Multiplex Associated with Systematic Vasculitis

Affiliations
  • 1Department of Neurology, Korea University, College of Medicine.
  • 2Department of Internal Medicine, Korea University, College of Medicine.

Abstract

Peripheral nervous system involvement is common in systemic vasculitis, occurring most frequently in the polyarteritis nodosa (PAN) group of disorders and in rheumatoid vasculitis. Within the polyarteritis nodosa group of systemic necrotizing vasculitides, three subgroups have been described: classic polyarteritis nodosa, Churg-Strauss syndrome, and an overlap syndrome. Three patients with evidence of systemic vasculitis and peripheral neuropathy were clinically and electrophysiologically investigated. All cases presented clinically with mononeuropathy multiples considered typical pattern of ischemic involvement of the peripheral nerve. The causes included polyarteritis nodosa, its Churg-strauss variant, and the overlap syndrome. Pain and weakness were frequent symptoms. Nerve conduction studies were abnormal In all cases. Necrotizing vasculitis was present as pathologic findings in two cases. All patients were treated with prednisolone alone or in combination with other immunosuppressive agents or with plasmapheresis.


MeSH Terms

Churg-Strauss Syndrome
Humans
Immunosuppressive Agents
Mononeuropathies*
Neural Conduction
Peripheral Nerves
Peripheral Nervous System
Peripheral Nervous System Diseases
Plasmapheresis
Polyarteritis Nodosa
Prednisolone
Rheumatoid Vasculitis
Systemic Vasculitis
Vasculitis*
Immunosuppressive Agents
Prednisolone
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