Infect Chemother.  2003 Jun;35(3):154-159.

Eradication Rate of Lansoprazole-Based Triple Therapy in Peptic Ulcer Patients with Helicobacter pylori and Efficacy of Urea Breath Test in Evaluating Helicobater pylori Eradication

• Jung HK
• Jin KJ
• You MA
• Bae KS
• Kwon JM
• Lee JS
• Kim DY
• Moon IH

Abstract

BACKGROUND: There are only a few studies on Helicobacter pylori (H. pylori) for its eradication rates of lansoprazole-based triple therapy in Korea, and the results are controversial. Therefore, we undertook to investigate the eradication rate of lansoprazole-based triple therapy, and compare the concordance rate of urea breath test (UBT) and rapid urease test (RUT) in evaluating H. pylori eradication.
METHODS
Patients with acute peptic ulcer who were H. pylori-positive were recruited by prospective, consecutive manner. They received lansoprazole 30 mg b.d., amoxicillin 1 g b.d. and clarithromycin 500 mg b.d. for 1 week. Upper endoscopy was performed after 4 weeks to check for ulcer healing, and UBT and RUT were performed to evaluate H. pylori eradication status.
RESULTS
A total of 46 patients were recruited, and they were all compliant. H. pylori eradication rate was 87.0% (40/46) and ulcer healing rate was 91.3% (42/46). Forty one patients showed negative in both UBT and RUT, and 4 patients revealed positive in both tests, therefore, the concordance rate of UBT and RUT was 97.8% (45/46).
CONCLUSION
Our study showed that 1-week lansoprazole-based triple therapy was effective in H. pylori eradication and ulcer healing. UBT can be an effective, noninvasive method for evaluating H. pylori status after H. pylori eradication.

Keyword

Helicobacter pylori; Eradication; Lansoprazole; Urea breath test

MeSH Terms

Amoxicillin
Breath Tests*
Clarithromycin
Endoscopy
Helicobacter pylori*
Helicobacter*
Humans
Korea
Lansoprazole
Peptic Ulcer*
Prospective Studies
Ulcer
Urea*
Urease
Amoxicillin
Clarithromycin
Urea
Urease